Encapsulator B-395 Pro

For sterile microbeads and microcapsules

A quality product for the sterile encapsulation of cells, biological and active ingredients for laboratory-scale research and development work. The highly advanced technology enables particle production for numerous biotechnology and medical processes and other fields that require sterile conditions.

What influences the final bead size?

Bead size is influenced by following parameters:

Nozzle size - major influence

Liquid flow rate - moderate influence

Vibration frequency - moderate influence

Physico-chemical properties of the encapsulation mixture - minor influence.

The most important parameter for bead production is the nozzle size. In general final bead diameter is about twice the size of the nozzle aperture.

Encapsulator

Benefits

Aseptic

Sterile encapsulation of cells, microorganisms and active ingredients
Aseptic introduction and removal of fluids and products to and from the reaction vessel
Possibility of integration in a GMP-compliant production process

Reliable

Efficient, reproducible encapsulation process under low-impact process conditions
Exceptionally tight particle size distribution
High encapsulation efficiency and yield

User-friendly

Intuitive to operate and easy to maintain
Quick and easy process optimization thanks to visualization of droplet formation
The BUCHI application database and BUCHI application support help you get the most out of working with the Encapsulator B-395 Pro

Voice of the customer

“The BUCHI Encapsulator B-395 Pro is the instrument of choice on the market for the sterile encapsulation of cells into polymeric beads and capsules, and is integretable into a GMP process.”

Prof. Bice Conti
Université de Pavia, Lab. Pharmaceutical Technology and Law (PT&L), Dept. Drug Sciences, Italie

Dimensions (W x D x H)	320 x 480 x 380 mm
Weight	11 kg
Power consumption	max. 150 W
Connection voltage	100-240 VAC
Frequency	50/60 Hz
Vibration frequency	40 to 6000 Hz
Electrode tension	250 to 2500 V
Nozzle diameter of single nozzles	0.08, 0.12, 0.15, 0.2, 0.3, 0.45, 0.75, 1.0 mm

Set of 8 single nozzles

Set of 8 single nozzles with high precision opening of 0.08, 0.12, 0.15, 0.20, 0.30, 0.45, 0.75 and 1.00 mm, made of stainless steel including nozzle rack.

Concentric nozzle set

Set of 7 external nozzles with high precision opening of 0.2, 0.3, 0.4, 0.5, 0.6, 0.7 and 0.9 mm made of stainless steel incl. 1000 mL pressure bottle

Reaction vessel for sterile apllications

Completely autoclavable reaction vessel made of glass and stainless steel for the sterile production and collection of microcapsules, 2 litre working volume; incl. bead producing unit and set of 8 single nozzles.

Air dripping nozzle set

Nozzle set for agglomerates and islet cells. Chamber, core nozzle 0.4mm, shell nozzle 1.5mm, air flow controller, incl. 2 short glass cylinders.

Flow vibration nozzle set

Nozzle set for high viscose solutions and smaller beads. Pulsation chamber core vibrated plus a set of 7 external nozzles with high precision opening of 0.2, 0.3, 0.4, 0.5, 0.6, 0.7 and 0.9 mm made of stainless steel, incl. air flow controller.

Features

Syringe pump

Easily calibrated syringe pump for low-loss feed of small sample quantities using sterile syringes of various volumes.

Material certificates

The reaction vessel for the Encapsulator B-395 Pro is available with material certificates for GMP documentation.

Concentric nozzle system

Concentric nozzle system for creating core-shell capsules (dia. 200 – 2000 µm).

Air dripping nozzle

Nozzle system with airstream dispersal and minimized dead space, tailor-made for low-impact encapsulation of cell agglomerates.

Applications

Spray Drying & Encapsulation Pharmaceuticals

Active pharmaceutical ingredients, drug delivery, vaccines, inhalable drugs, taste masking

Spray Drying & Encapsulation Food

Encapsulation of additives, controlled release, nutraceuticals, functional foods, flavors, vitamins, proteins, probiotic bacteria, juice concentrate, milk powder